Co-administration of metformin and vitamin C or E in improves diabetes prognosis in streptozotocin-induced diabetes rats

The prevalence of diabetes mellitus has increased astronomically in recent years. This resulted disease adjusted life years (DALYs), mortality and decrease expectancy. Some the fall outs diabetic patients include hyperlipidaemia, oxidative stress, renal hepatic dysfunction. study investigated combined effects metformin with either vitamin C or E on hyperglycemia-induced hyperlipidemia, Diabetes was induced animals fasted overnight a single dose streptozotocin (40 mg/kg, intraperitoneal). Animals fasting blood glucose (FBG) levels >200 mg/dl after 48 hours administration were marked randomly grouped into 6 groups 5 rats each. Treatments administered orally once daily for two weeks. FBG levels, other parameters determined. results showed that various treatments significantly comparably reduced both day 7 (p<0.05, P<0.01) 14 (p<0.001). All increase triglyceride (TG), total cholesterol (TC), alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate (AST), creatinine malondialdehyde (MDA). antioxidant enzyme activity superoxide dismutase (SOD), glutathione reductase (GSH), catalase (CAT) enhanced by E. Vitamin combination did not prevent induced-weight loss throughout compared to control. findings have demonstrated co-administration exhibits synergistic lowering effect, potential advantage preventing multi-organ damaging type 2 diabetes.